GM-CSF-mediated impairment of liver to synthesize albumin, cholinesterase, and cholesterol.

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Takahashi M, Nikkuni K, Moriyama Y, Shibata A

GM-CSF-mediated impairment of liver to synthesize albumin, cholinesterase, and cholesterol.

Am J Hematol. 1991 Mar;36(3):213-4.

PubMed ID

1996559 [ View in PubMed

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Abstract

Serum albumin, cholinesterase, and cholesterol were measured in ten patients with aplastic anemia and eight with myelodysplastic syndrome who received the administration of recombinant human GM-CSF. Serum albumin, cholinesterase, and cholesterol were significantly lowered by the administration of GM-CSF and recovered after the cessation of GM-CSF. These data suggest that GM-CSF impairs the biosynthesis of liver cells and that cholesterol-lowering activity of GM-CSF, which is previously reported, is due to the impairment of liver biosynthesis by GM-CSF.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Regramostim	Cholinesterase	Protein	Humans	Unknown	Inhibitor	Details