Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes.
Article Details
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Kneip C, Terlinden R, Beier H, Chen G
Investigations into the drug-drug interaction potential of tapentadol in human liver microsomes and fresh human hepatocytes.
Drug Metab Lett. 2008 Jan;2(1):67-75.
- PubMed ID
- 19356073 [ View in PubMed]
- Abstract
The new analgesic tapentadol was evaluated for induction and inhibition of several cytochrome P450 enzymes in vitro, and protein binding was assessed. It was concluded that no clinically relevant drug-drug interactions are likely to occur through either mechanism.
DrugBank Data that Cites this Article
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Tapentadol Cytochrome P450 2C19 Protein Humans UnknownSubstrateDetails Tapentadol Cytochrome P450 2C9 Protein Humans UnknownSubstrateDetails Tapentadol UDP-glucuronosyltransferase 1-9 Protein Humans UnknownSubstrateDetails Tapentadol UDP-glucuronosyltransferase 2B7 Protein Humans UnknownSubstrateDetails