Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation.

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Clement Y, Le Guisquet AM, Venault P, Chapouthier G, Belzung C

Pharmacological alterations of anxious behaviour in mice depending on both strain and the behavioural situation.

PLoS One. 2009 Nov 11;4(11):e7745. doi: 10.1371/journal.pone.0007745.

PubMed ID

19907641 [ View in PubMed

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Abstract

A previous study comparing non-emotive mice from the strain C57BL/6/ByJ with ABP/Le mice showed ABP/Le to be more anxious in an open-field situation. In the present study, several compounds affecting anxiety were assayed on ABP/Le and C57BL/6/ByJ mice using three behavioural models of anxiety: the elevated plus-maze, the light-dark discrimination test and the free exploratory paradigm. The compounds used were the full benzodiazepine receptor agonist, chlordiazepoxide, and the antagonist, flumazenil, the GABA(A) antagonist, bicuculline, the full 5-HT(1A) agonist 8-OH-DPAT, and the mixed 5-HT(1A)/5-HT(1B) agonist, RU 24969. Results showed the effect of the compounds to be dependent on both the strain and the behavioural task. Several compounds found to be anxiolytic in ABP/Le mice had an anxiogenic effect on C57BL/6/ByJ mice. More behavioural changes were observed for ABP/Le in the elevated plus-maze, but the clearest findings for C57BL/6/ByJ mice were observed in the light-dark discrimination apparatus. These data demonstrate that anxious behaviour is a complex phenomenon which cannot be described by a single behavioural task nor by the action of a single compound.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Flumazenil	Gamma-aminobutyric acid receptor subunit alpha-5	Protein	Humans	Yes	Antagonist	Details