The effect of GR38032F, novel 5-HT3-receptor antagonist on gastric emptying in the guinea-pig.

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Costall B, Gunning SJ, Naylor RJ, Tyers MB

The effect of GR38032F, novel 5-HT3-receptor antagonist on gastric emptying in the guinea-pig.

Br J Pharmacol. 1987 Jun;91(2):263-4.

PubMed ID
2955843 [ View in PubMed
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Abstract

The effects of GR38032F a novel, selective and potent 5-hydroxytryptamine (5-HT3)-receptor antagonist on gastric emptying in the guinea-pig were investigated and compared to those of metoclopramide and haloperidol. Both GR38032F and metoclopramide increased gastric emptying in a dose-dependent manner. In contrast, haloperidol was ineffective. GR38032F was about 200 times more potent than metoclopramide in enhancing gastric emptying over the 2 h period studied.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Metoclopramide5-hydroxytryptamine receptor 3AProteinHumans
Yes
Antagonist
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