Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination.

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Adam D, de Visser I, Koeppe P

Pharmacokinetics of amoxicillin and clavulanic acid administered alone and in combination.

Antimicrob Agents Chemother. 1982 Sep;22(3):353-7. doi: 10.1128/aac.22.3.353.

PubMed ID
7137979 [ View in PubMed
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Abstract

The pharmacokinetics of amoxicillin and clavulanic acid, administered alone and in combination, were studied in six male and six female normal human volunteers. Each ingested 500 mg of amoxicillin or 125 mg of clavulanic acid or the above agents in combination in randomized sequences. The results indicate that most of the parameters tested for either substance are essentially independent of the presence of the other one.

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