Spironolactone and endocrine dysfunction.

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Spironolactone and endocrine dysfunction.

Ann Intern Med. 1976 Nov;85(5):630-6.

PubMed ID

984618 [ View in PubMed

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Abstract

Therapy with spironolactone is often associated with estrogenlike side-effects, including impotence and gynecomastia in men and menstrual irregularity in women. Several possible mechanisms by which spironolactone could cause these side-effects have been identified. Spironolactone has been shown to affect both gonadal and adrenal steroidogenesis, to elevate plasma gonadotrophin levels in children, and to act as an antiandrogen at the target tissue level. This conference presents a discussion of how these effects might interact to produce the endocrine side effects associated with spironolactone therapy.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Spironolactone	Approved	17-hydroxyprogesterone	increased	Spironolactone increases the level of 17-hydroxyprogesterone in the blood
Spironolactone	Approved	Progesterone	increased	Spironolactone increases the level of Progesterone in the blood
Spironolactone	Approved	Testosterone	increased	Spironolactone increases the level of Testosterone in the blood