Distribution of 99mTc-labeled lymphocytes in control and inflamed rats.

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Fulgenzi A, Casati R, Colombo FR, Gasparini M, Ferrero E, Bondanza A, Gerundini P, Ferrero ME

Distribution of 99mTc-labeled lymphocytes in control and inflamed rats.

Nucl Med Biol. 2004 Jul;31(5):631-8.

PubMed ID
15219282 [ View in PubMed
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Abstract

We studied the in vivo fate of CD8(+) lymphocytes, of naive (CD8(+)CD45RC(bright)) or memory (CD8(+)CD45RC(dim)) phenotype, injected in syngeneic rats, after their sorting and labeling with [(99m)Tc] HM-PAO. By using the scintigrafic method we showed that memory CD8(+) lymphocytes were able to recirculate into liver and lungs. The same method was also successfully used to in vivo study the homing of total blood lymphocytes obtained from inflamed rats.

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