Sequencing of two new HLA class II alleles: DRB3*0218 and DQB1*030202.
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Balas A, Aviles MJ, Lillo R, Alonso-Nieto M, Zarapuz L, Garcia-Villaescusa R, Garcia-Sanchez F, Vicario JL
Sequencing of two new HLA class II alleles: DRB3*0218 and DQB1*030202.
Tissue Antigens. 2004 Jun;63(6):614-6. doi: 10.1111/j.0001-2815.2004.00196.x.
- PubMed ID
- 15140047 [ View in PubMed]
- Abstract
Two novel human leukocyte antigen (HLA) class II alleles for DRB3 and DQB1 genes detected in Caucasoid Spanish individuals are described: DRB3*0218 and DQB1*030202. Both alleles have been found during routine high-resolution typing by sequencing. DRB3*0218 shows a novel DRB3 gene polymorphic position, located at amino acid residue 58, alanine to glutamic acid. This residue is shared by several DRB1 alleles, including all described DRB1*11 subtypes. DQB1*030202 differs from DQB1*030201 by a point mutation at position 319 (T to C). This nucleotide change generates a new codon at amino acid position 75 that is not shared by any other DQB1 allele.