A splice variant of Dp71 lacking the syntrophin binding site is expressed in early stages of human neural development.
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Ceccarini M, Rizzo G, Rosa G, Chelucci C, Macioce P, Petrucci TC
A splice variant of Dp71 lacking the syntrophin binding site is expressed in early stages of human neural development.
Brain Res Dev Brain Res. 1997 Oct 20;103(1):77-82. doi: 10.1016/s0165-3806(97)00122-3.
- PubMed ID
- 9370062 [ View in PubMed]
- Abstract
Dp71, a 71 kDa C-terminal isoform of dystrophin, is the major product of the DMD gene in brain. Two alternatively spliced transcripts of Dp71 were amplified by RT-PCR from different areas of human fetal neural tissue. Both transcripts were spliced out of exons 71 and 78. The shorter transcript was also alternatively spliced of exons 72-74, a region comprising the coding sequence for the binding site to syntrophin, one component of the dystrophin-associated protein complex. Results indicate that alternatively spliced forms of Dp71 are regulated during human neural development.