A Drug-drug Interaction Between Cyclosporine and Nystatin.

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Liu W, Guan X, Yu Z, Chen K, Benet L, Zhai S

A Drug-drug Interaction Between Cyclosporine and Nystatin.

Clin Ther. 2018 Apr;40(4):660-662. doi: 10.1016/j.clinthera.2018.02.008. Epub 2018 Mar 16.

PubMed ID

29551534 [ View in PubMed

]

Abstract

We present a case of increased cyclosporine concentration and liver function right after the combinational use of cyclosporine and nystatin, which indicated a drug-drug interaction between them. Both the concentration and liver function were decreased after discontinuation of nystatin and remained normal after taking on cyclosporine again. To our knowledge, this is the first case report of the interactions between nystatin and cyclosporine. Enteric P-glycoprotein could play an important role in the pharmacokinetic profile of cyclosporine, which needs further identification by physicians and pharmacists.

DrugBank Data that Cites this Article

Drugs

Nystatin

Drug Interactions

Drugs	Interaction
Integrate drug-drug interactions in your software
Cyclosporine Nystatin	The serum concentration of Cyclosporine can be increased when it is combined with Nystatin.