Interaction between antidepressants and alpha-adrenergic receptor blocking agents.

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Zebrowska-Lupina I, Kozyrska C, Stelmasiak M

Interaction between antidepressants and alpha-adrenergic receptor blocking agents.

Pol J Pharmacol Pharm. 1980 Sep-Oct;32(5):673-80.

PubMed ID

6115370 [ View in PubMed

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Abstract

Yohimbine and phentolamine administered in doses regarded as blocking presynaptic alpha-adrenoreceptors counteracted locomotor sedation elicited in rats by antidepressant drugs (imipramine, nortriptyline and amitriptyline). The reduction of noradrenaline (NA) utilization in the brain evoked by a single dose of antidepressants and the increase of NA utilization induced by chronic treatment with imipramine or nortriptyline were prevented by yohimbine. The results indicate the role of presynaptic alpha-adrenoceptors in the influence of tricyclic antidepressants on NA neurons in the brain.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Nortriptyline	Alpha-2 adrenergic receptors (Protein Group)	Protein group	Humans	Unknown	Antagonist	Details