Corticosteroids and human recombinant activated protein C for septic shock.

Article Details

Citation

Colin G, Annane D

Corticosteroids and human recombinant activated protein C for septic shock.

Clin Chest Med. 2008 Dec;29(4):705-12, x. doi: 10.1016/j.ccm.2008.06.009.

PubMed ID
18954704 [ View in PubMed
]
Abstract

This article summarizes the current knowledge on the benefit/risk profile from the use of low-dose corticosteroids and activated protein C in treating septic shock. Physicians should consider using low-dose corticosteroids and drotrecogin alpha activated in the treatment of patients who have vasopressor-dependent septic shock with persistent signs of hypoperfusion, organ dysfunction, or hypotension. The optimal timing for initiating these treatments is from 6 to 24 hours from onset of shock. When patients are receiving these drugs, physicians should systematically screen for superinfection and serious bleeding events.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Drotrecogin alfaCoagulation factor VIIIProteinHumans
Yes
Multitarget
Details