Pharmacokinetics of viloxazine hydrochloride in man.
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Vandel B, Vandel S, Jounet JM, Blum D
Pharmacokinetics of viloxazine hydrochloride in man.
Eur J Drug Metab Pharmacokinet. 1982 Jan-Mar;7(1):65-8.
- PubMed ID
- 7067726 [ View in PubMed]
- Abstract
The pharmacokinetic characteristics of a new antidepressant, viloxazine hydrochloride, were investigated in five males and five females to study sex differences. Plasma levels were determined over a period of 9 h after a single dose of viloxazine of 100 mg (expressed as base). The half life of the drug was in the range of 2.19 - 4.21 for females and 2.61 - 4.31 h for males. The maximum plasma levels occurred in 29 - 171 min of the oral dose for females and 54 - 155 min for males. They reached 1382 - 1769 ng/ml-l for females and 1108 - 2932 ng/ml for males. Pharmacokinetic data were not statistically different between males and females.