Comparative binding study of aluminum and chromium to human transferrin. Effect of iron.

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Moshtaghie AA, Ani M, Bazrafshan MR

Comparative binding study of aluminum and chromium to human transferrin. Effect of iron.

Biol Trace Elem Res. 1992 Jan-Mar;32:39-46.

PubMed ID
1375080 [ View in PubMed
]
Abstract

The characteristics of aluminum and chromium binding to apo-transferrin (apo-tf) have been investigated and compared. Both metal ions were taken up by human transferrin forming complexes with the maximum absorbances at 405 nm for chromium-transferrin (cr-tf) and 240 nm for aluminum-transferrin (Al-tf). In the presence of citric acid, chromium binding to transferrin is five times more than aluminum. The binding of aluminum or chromium to apo-transferrin was reduced by 18 and 22% in the presence of 200 ng/mL of iron. The binding of both metals to apo-tf appears to be pH dependent. In acidic pHs, less chromium and more aluminum binding occurred.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
Chromic citrateSerotransferrinProteinHumans
Unknown
Not AvailableDetails
Chromic nitrateSerotransferrinProteinHumans
Unknown
Not AvailableDetails
ChromiumSerotransferrinProteinHumans
Unknown
Binder
Details
Chromium gluconateSerotransferrinProteinHumans
Unknown
Not AvailableDetails
Chromium nicotinateSerotransferrinProteinHumans
Unknown
Not AvailableDetails
Chromous sulfateSerotransferrinProteinHumans
Unknown
Not AvailableDetails