How does infliximab work in rheumatoid arthritis?
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Maini RN, Feldmann M
How does infliximab work in rheumatoid arthritis?
Arthritis Res. 2002;4 Suppl 2:S22-8. Epub 2002 Mar 27.
- PubMed ID
- 12110154 [ View in PubMed]
- Abstract
Since the initial characterization of tumor necrosis factor alpha (TNFalpha), it has become clear that TNFalpha has diverse biologic activity. The realization that TNFalpha plays a role in rheumatoid arthritis (RA) has led to the development of anti-TNF agents for the treatment of RA. Infliximab, a chimeric monoclonal antibody that specifically, and with high affinity, binds to TNFalpha and neutralizes the cytokine, is currently approved for the treatment of RA and Crohn's disease, another immune-inflammatory disorder. In addition to establishing the safety and efficacy of infliximab, clinical research has also provided insights into the complex cellular and cytokine-dependent pathways involved in the pathophysiology of RA, including evidence that supports TNFalpha involvement in cytokine regulation, cell recruitment, angiogenesis, and tissue destruction.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Infliximab Tumor necrosis factor Protein Humans YesInhibitorDetails