Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP).
Article Details
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Arnaud J, Constans J
Affinity differences for vitamin D metabolites associated with the genetic isoforms of the human serum carrier protein (DBP).
Hum Genet. 1993 Sep;92(2):183-8.
- PubMed ID
- 8370586 [ View in PubMed]
- Abstract
Human vitamin D binding protein (DBP) displays considerable polymorphism with 120 described alleles. Among these, three alleles are frequently observed, Gc 1F (pI 4.94-4.84), Gc 1S (pI 4.95-4.85) and Gc 2 (pI 5.1). Differences between these genetic forms of the protein in affinity for vitamin D metabolites have been detected by electrophoretic methods. The constant affinity (Ka) values determined in this study confirm these differences. The affinities of six rare variants were also examine. Those of the DBP genetic forms to the vitamin D derivatives 25-OH-D3 and 1,25-(OH)2-D3 seem to be related to the isoelectric point of the proteins: a high affinity corresponding to a low isoelectric point. The Gc 1A9 and 1A11 mutants were associated with higher affinity for the vitamin D derivatives and the Gc 1C1 and 1C21 mutants were deficient.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Vitamin D Vitamin D-binding protein Protein Humans UnknownNot Available Details - Drug Carriers
Drug Carrier Kind Organism Pharmacological Action Actions Calcitriol Vitamin D-binding protein Protein Humans NoBinderDetails