ERalpha, A Key Target for Cancer Therapy: A Review.

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Liu Y, Ma H, Yao J

ERalpha, A Key Target for Cancer Therapy: A Review.

Onco Targets Ther. 2020 Mar 11;13:2183-2191. doi: 10.2147/OTT.S236532. eCollection 2020.

PubMed ID
32210584 [ View in PubMed
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Abstract

Estrogen receptor alpha (ERalpha) is closely associated with both hormone-dependent and hormone-independent tumors, and it is also essential for the development of these cancers. The functions of ERalpha are bi-faceted; it can contribute to cancer progression as well as cancer inhibition. Therefore, understanding ERalpha is vital for the treatment of those cancers that are closely associated with its expression. Here, we will elaborate on ERalpha based on its structure, localization, activation, modification, and mutation. Also, we will look at co-activators of ERalpha, elucidate the signaling pathway activated by ERalpha, and identify cancers related to its activation. A comprehensive understanding of ERalpha could help us to find new ways to treat cancers.

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