Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2.

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Renn A, Fu Y, Hu X, Hall MD, Simeonov A

Fruitful Neutralizing Antibody Pipeline Brings Hope To Defeat SARS-Cov-2.

Trends Pharmacol Sci. 2020 Nov;41(11):815-829. doi: 10.1016/j.tips.2020.07.004. Epub 2020 Jul 31.

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32829936 [ View in PubMed
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Abstract

With the recent spread of severe acute respiratory syndrome coronavirus (SARS-CoV-2)_ infecting >16 million people worldwide as of 28 July 2020, causing >650 000 deaths, there is a desperate need for therapeutic agents and vaccines. Building on knowledge of previous outbreaks of SARS-CoV-1 and Middle East respiratory syndrome (MERS), the development of therapeutic antibodies and vaccines against coronavirus disease 2019 (COVID-19) is taking place at an unprecedented speed. Current efforts towards the development of neutralizing antibodies against COVID-19 are summarized. We also highlight the importance of a fruitful antibody development pipeline to combat the potential escape plans of SARS-CoV-2, including somatic mutations and antibody-dependent enhancement (ADE).

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