The molybdenum cofactor.

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Mendel RR

The molybdenum cofactor.

J Biol Chem. 2013 May 10;288(19):13165-72. doi: 10.1074/jbc.R113.455311. Epub 2013 Mar 28.

PubMed ID

23539623 [ View in PubMed

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Abstract

The transition element molybdenum needs to be complexed by a special cofactor to gain catalytic activity. Molybdenum is bound to a unique pterin, thus forming the molybdenum cofactor (Moco), which, in different variants, is the active compound at the catalytic site of all molybdenum-containing enzymes in nature, except bacterial molybdenum nitrogenase. The biosynthesis of Moco involves the complex interaction of six proteins and is a process of four steps, which also require iron, ATP, and copper. After its synthesis, Moco is distributed, involving Moco-binding proteins. A deficiency in the biosynthesis of Moco has lethal consequences for the respective organisms.

DrugBank Data that Cites this Article

Drugs

Fosdenopterin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Fosdenopterin	Molybdopterin synthase catalytic subunit	Protein	Humans	Yes	Substrate	Details