CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.
Article Details
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Tripp RA, Jones LP, Haynes LM, Zheng H, Murphy PM, Anderson LJ
CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.
Nat Immunol. 2001 Aug;2(8):732-8. doi: 10.1038/90675.
- PubMed ID
- 11477410 [ View in PubMed]
- Abstract
Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokine mimicry for the G glycoprotein of respiratory syncytial virus (RSV) and show binding to CX3CR1--the specific receptor for the CX3C chemokine fractalkine--and induction of leukocyte chemotaxis. We also show that CX3CR1 facilitates RSV infection of cells. Thus, G glycoprotein interaction with CX3CR1 probably plays a key role in the biology of RSV infection.