Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.
Article Details
- CitationCopy to clipboard
Faure S, Meyer L, Costagliola D, Vaneensberghe C, Genin E, Autran B, Delfraissy JF, McDermott DH, Murphy PM, Debre P, Theodorou I, Combadiere C
Rapid progression to AIDS in HIV+ individuals with a structural variant of the chemokine receptor CX3CR1.
Science. 2000 Mar 24;287(5461):2274-7. doi: 10.1126/science.287.5461.2274.
- PubMed ID
- 10731151 [ View in PubMed]
- Abstract
Human immunodeficiency virus (HIV) enters cells in vitro via CD4 and a coreceptor. Which of 15 known coreceptors are important in vivo is poorly defined but may be inferred from disease-modifying mutations, as for CCR5. Here two single nucleotide polymorphisms are described in Caucasians in CX3CR1, an HIV coreceptor and leukocyte chemotactic/adhesion receptor for the chemokine fractalkine. HIV-infected patients homozygous for CX3CR1-I249 M280, a variant haplotype affecting two amino acids (isoleucine-249 and methionine-280), progressed to AIDS more rapidly than those with other haplotypes. Functional CX3CR1 analysis showed that fractalkine binding is reduced among patients homozygous for this particular haplotype. Thus, CX3CR1-I249 M280 is a recessive genetic risk factor in HIV/AIDS.