HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.
Article Details
- CitationCopy to clipboard
Goodridge JP, Burian A, Lee N, Geraghty DE
HLA-F and MHC class I open conformers are ligands for NK cell Ig-like receptors.
J Immunol. 2013 Oct 1;191(7):3553-62. doi: 10.4049/jimmunol.1300081. Epub 2013 Sep 9.
- PubMed ID
- 24018270 [ View in PubMed]
- Abstract
Killer Ig-like receptors (KIRs) are innate immune receptors expressed by NK and T cells classically associated with the detection of missing self through loss of their respective MHC ligand. Some KIR specificities for allelic classical class I MHC (MHC-I) have been described, whereas other KIR receptor-ligand relationships, including those associated with nonclassical MHC-I, have yet to be clearly defined. We report in this article that KIR3DL2 and KIR2DS4 and the nonclassical Ag HLA-F, expressed as a free form devoid of peptide, physically and functionally interact. These interactions extend to include classical MHC-I open conformers as ligands, defining new relationships between KIR receptors and MHC-I. The data collectively suggest a broader, previously unrecognized interaction between MHC-I open conformers--including prototypical HLA-F--and KIR receptors, acting in an immunoregulatory capacity centered on the inflammatory response.