Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706.
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Vilches C, Bunce M, Sanz L, de Pablo R, Puente S, Kreisler M
Molecular cloning of two new HLA-C alleles: Cw*1801 and Cw*0706.
Tissue Antigens. 1996 Dec;48(6):698-702. doi: 10.1111/j.1399-0039.1996.tb02694.x.
- PubMed ID
- 9008313 [ View in PubMed]
- Abstract
Nucleotide sequence analysis of the HLA-C alleles of the GB92 cell line, heterozygous for B*8101 and B*4407, revealed the existence of two new allelic variants: Cw*1801 and Cw*0706. The former allele, initially detected as a PCR-SSP variant, displays a hybrid aspect, sharing sequence motifs with Cw*07 at exons 1 and 2, and with Cw*04 at distal exons. In serological assays, Cw*1801 is only recognized by some cross-reactive sera. Cw*0706 shows a primary structure closely related to previously known Cw7 alleles, but carries new sequence motifs at its 3'-end. Preliminary data indicate that Cw*1801 is associated to B*8101 and that Cw*0706, B*4407 could account for a part of the Cw7, B44 haplotypes observed in African populations.