Cw*1701 defines a divergent african HLA-C allelic lineage.
Article Details
- CitationCopy to clipboard
Wells RS, Seielstad MT, Bunce M, Tyan DB, Bekele E, Parham P
Cw*1701 defines a divergent african HLA-C allelic lineage.
Immunogenetics. 1997;46(3):173-80. doi: 10.1007/s002510050259.
- PubMed ID
- 9211742 [ View in PubMed]
- Abstract
The complete sequence of a new HLA-C allele, Cw*1701, was determined from a South African Zulu individual. Unique features that distinguish Cw*1701 from other HLA-C alleles include multiple point substitutions and an 18 nucleotide insertion in exon 5, which encodes the transmembrane domain. In a phylogenetic analysis of HLA-C sequences, Cw*1701 forms a third, distinct allelic lineage. A comparison of the transmembrane domain of Cw*1701 with other HLA-B and -C alleles reveals that duplications and deletions have been common in the evolution of these loci. A polymerase chain reaction based typing method was used to determine the distribution of this unusual allele in human populations. In contrast to the other two lineages of HLA-C alleles, the Cw*17 lineage is found at high frequencies only in populations of African descent. In addition, the HLA-B/Cw*17 haplotype diversity is higher in Africa.