Amobarbital metabolism in man: N-glucoside formation.

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Tang BK, Kalow W, Grey AA

Amobarbital metabolism in man: N-glucoside formation.

Res Commun Chem Pathol Pharmacol. 1978 Jul;21(1):45-53.

PubMed ID
684279 [ View in PubMed
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Abstract

N-Hydroxyamobarbital, the compound previously proposed as the second major metabolite of amobarbital was synthesized. The metabolite was shown not to be N-hydroxyamobarbital. NMR and MS analyses on the metabolite suggested it could be a derivative of N-beta-D-glucopyranoside. This proposed structure was confirmed by comparison with the spectral data of synthetic amobarbital-N-methyl-N-2,3,4,6-tetraacetyl-beta-D-glucopyranoside.

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