Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.
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Suzuki T, Yamamoto M
Stress-sensing mechanisms and the physiological roles of the Keap1-Nrf2 system during cellular stress.
J Biol Chem. 2017 Oct 13;292(41):16817-16824. doi: 10.1074/jbc.R117.800169. Epub 2017 Aug 24.
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- 28842501 [ View in PubMed]
- Abstract
Transcription factor Nrf2 (NF-E2-related factor 2) is a master regulator of cellular responses against environmental stresses. Nrf2 induces the expression of detoxification and antioxidant enzymes and suppresses the induction of pro-inflammatory cytokine genes. Keap1 (Kelch-like ECH-associated protein 1) is an adaptor subunit of Cullin 3-based E3 ubiquitin ligase. Keap1 regulates the activity of Nrf2 and acts as a sensor for oxidative and electrophilic stresses. In this review, we discuss the molecular mechanisms by which the Keap1-Nrf2 system senses and regulates the cellular response to environmental stresses. In particular, we focus on the multiple stress-sensing mechanisms of Keap1 and novel regulatory functions of Nrf2.