Blood-gas changes during induced hypotension with sodium nitroprusside.

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Wildsmith JA, Drummond GB, MacRae WR

Blood-gas changes during induced hypotension with sodium nitroprusside.

Br J Anaesth. 1975 Nov;47(11):1205-11.

PubMed ID

766790 [ View in PubMed

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Abstract

A blood-gas study of the respiratory effects of sodium nitroprusside during anaesthesia has shown a marked reduction in PaO2 when the drug was administered. After nitroprusside PaO2 returned to the previous values. It is suggested that the reduction in PaO2 is a result of an increased scatter of ventilation/perfusion relationships in the lung. The reduction in PaO2 was evident during both spontaneous and artificial ventilation. Nitroprusside was associated with a small decrease in actual bicarbonate.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Nitroprusside	Approved Investigational	Bicarbonate	decreased	Nitroprusside decreases the level of Bicarbonate in the blood