Effect of sex hormones on the excretion of free histamine by male and female rats.

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MARSHALL PB

Effect of sex hormones on the excretion of free histamine by male and female rats.

Br J Pharmacol Chemother. 1961 Feb;16:50-8. doi: 10.1111/j.1476-5381.1961.tb00297.x.

PubMed ID

13767230 [ View in PubMed

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Abstract

The excretion of free histamine by male rats was increased 10-fold by treatment with oestrogen or castration. That of female rats was reduced to 1/10 by treatment with testosterone. Ovariectomy further increased the histamine excretion by female rats, which was slightly reduced by treatment with oestrogen, and at oestrus. The low level of free histamine excretion by male rats was not increased by compound SKF 525-A, and inhibition of diamine oxidase by aminoguanidine caused the same proportionate increase in both sexes. It is concluded that the conjugation of histamine by male rats requires the presence of androgens, and some preliminary indication is given regarding the possible mechanisms involved.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Pimagedine	Amiloride-sensitive amine oxidase [copper-containing]	Protein	Humans	Yes	Inhibitor	Details