Comparative study of bezafibrate and fenofibrate in patients with primary hyperlipoproteinaemia.

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Tesone PA, Gladstein J, Acuna AM

Comparative study of bezafibrate and fenofibrate in patients with primary hyperlipoproteinaemia.

Curr Med Res Opin. 1985;9(9):650-7.

PubMed ID

3902379 [ View in PubMed

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Abstract

A study was carried out in 40 patients with primary hyperlipoproteinaemia to compare the efficacy and tolerance of bezafibrate and fenofibrate, combined with a dietary regimen, in reducing lipid levels. Patients were allocated at random to receive treatment for 4 months with either 600 mg bezafibrate or 300 mg fenofibrate per day. Efficacy of treatment was assessed from measurement before and after treatment of the levels of total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides and blood glucose. Tolerance was monitored by monthly clinical examinations and routine investigation of blood chemistry and urinalysis before and after treatment. The results indicated that bezafibrate was a more effective normolipaemic agent than fenofibrate. Whilst both drugs reduced triglyceride levels significantly, only in the bezafibrate group were they decreased to within the risk-free range. Bezafibrate also produced a significant decrease in total cholesterol and LDL-cholesterol to near the risk-free level and an increase in HDL-cholesterol. With fenofibrate, total cholesterol and LDL-cholesterol levels remained within the range necessitating treatment and HDL-cholesterol showed little if any change. Although there were decreases in alkaline phosphatase and significant decreases in gamma-glutamyl transpeptidase levels in both groups after treatment, there was a tendency for SGPT, SGOT, total bilirubin and direct bilirubin levels to increase after fenofibrate but to decrease after bezafibrate.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Fenofibrate	Approved	Total bilirubin	increased	Fenofibrate increases the level of Total bilirubin in the blood
Fenofibrate	Approved	Direct bilirubin	increased	Fenofibrate increases the level of Direct bilirubin in the blood
Bezafibrate	Approved Investigational	Bilirubin	decreased	Bezafibrate decreases the level of Bilirubin in the blood
Fenofibrate	Approved	Triglycerides	decreased	Fenofibrate decreases the level of Triglycerides in the blood