The effect of various regimens of hormone therapy on serum cholesterol and triglyceride concentrations in postmenopausal women.

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Paterson ME, Sturdee DW, Moore B, Whitehead TP

The effect of various regimens of hormone therapy on serum cholesterol and triglyceride concentrations in postmenopausal women.

Br J Obstet Gynaecol. 1980 Jul;87(7):552-60.

PubMed ID

6252948 [ View in PubMed

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Abstract

The serum cholesterol and triglyceride concentrations of 84 postmenopausal women both before and after 2, 6 and 12 months therapy with various regimens of hormone therapy were measured. There was little alteration in mean serum cholesterol concentration with cyclical oestrogens but both sequential mestranol and norethisterone and sequential oestradiol valerate and norgestrel significantly reduced the mean serum cholesterol concentration to a level similar to that found in age-matched premenopausal women. There was a small and sometimes significant rise in serum triglyceride concentration with cyclical oestrogens. Sequential mestranol and norethisterone significantly elevated serum triglyceride levels, but sequential oestradiol valerate and norgestrel significantly depressed them. The results suggest that the progestogenic agent norgestrel has an important role to play in reducing both serum cholesterol and triglyceride levels, and that the sequential preparations, by virtue of their greater cholesterol lowering effect, should perhaps be preferred to cyclical oestrogens.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Mestranol	Approved	Triglycerides	increased	Mestranol increases the level of Triglycerides in the blood
Norethisterone	Approved	Triglycerides	increased	Norethisterone increases the level of Triglycerides in the blood
Norgestrel	Approved	Triglycerides	decreased	Norgestrel decreases the level of Triglycerides in the blood
Norgestrel	Approved	Cholesterol	decreased	Norgestrel decreases the level of Cholesterol in the blood