The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis.

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Bourke JF, Mumford R, Whittaker P, Iqbal SJ, Le Van LW, Trevellyan A, Hutchinson PE

The effects of topical calcipotriol on systemic calcium homeostasis in patients with chronic plaque psoriasis.

J Am Acad Dermatol. 1997 Dec;37(6):929-34.

PubMed ID

9418759 [ View in PubMed

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Abstract

BACKGROUND: Calcipotriol is an effective treatment of chronic plaque psoriasis. We have previously demonstrated that it has a small effect on systemic calcium homeostasis even at recommended doses. OBJECTIVE: We attempted to determine the mechanism of the effect of calcipotriol on systemic calcium homeostasis so we could assess the possible consequences of long-term use. METHODS: Sixteen patients with extensive chronic plaque psoriasis were hospitalized and treated with high-dose topical calcipotriol. Up to 360 gm of calcipotriol (50 micrograms/gm) ointment was applied per week for 2 weeks under controlled conditions. RESULTS: There was a dose-dependent rise in intestinal absorption of calcium. No effect on bone turnover was demonstrated over this short period. Five patients became hypercalcemic, and there was a dose-dependent rise in serum total adjusted calcium, serum ionized calcium, serum phosphate, urine calcium, and urine phosphate. There was a dose-dependent fall in serum parathyroid hormone and serum 1,25 dihydroxyvitamin D3. CONCLUSION: Calcipotriol exerts its effects on systemic calcium homeostasis by increasing intestinal absorption of calcium and probably phosphate. This results in suppression of parathyroid hormone and 1,25 dihydroxyvitamin D3.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Calcipotriol	Approved	Calcium	increased	Calcipotriol increases the level of Calcium in the blood
Calcipotriol	Approved	Phosphate	increased	Calcipotriol increases the level of Phosphate in the blood
Calcipotriol	Approved	1,25-dihydroxyvitamin D3	decreased	Calcipotriol decreases the level of 1,25-dihydroxyvitamin D3 in the blood