Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia.

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Bilz S, Wagner S, Schmitz M, Bedynek A, Keller U, Demant T

Effects of atorvastatin versus fenofibrate on apoB-100 and apoA-I kinetics in mixed hyperlipidemia.

J Lipid Res. 2004 Jan;45(1):174-85. Epub 2003 Oct 1.

PubMed ID

14523053 [ View in PubMed

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Abstract

Kinetics of apo B and apo AI were assessed in 8 patients with mixed hyperlipidemia at baseline and after 8 weeks of atorvastatin 80 mg q.d. and micronised fenofibrate 200 mg q.d. in a cross-over study. Both increased hepatic production and decreased catabolism of VLDL accounted for elevated cholesterol and triglyceride concentrations at baseline. Atorvastatin significantly decreased triglyceride, total, VLDL and LDL cholesterol and apo B concentrations (-65%, -36%, -57%, -40% and -33%, respectively, P<0.05). Kinetic analysis revealed that atorvastatin stimulated the catabolism of apo B containing lipoproteins, enhanced the delipidation of VLDL1 and decreased VLDL1 production. Fenofibrate lowered triglycerides and VLDL cholesterol (-57% and -64%, respectively, P<0.05) due to enhanced delipidation of VLDL1 and VLDL2 and increased VLDL1 catabolism. Changes of HDL particle composition accounted for the increase of HDL cholesterol during atorvastatin and fenofibrate (18% and 23%, P<0.01). Only fenofibrate increased apo AI concentrations through enhanced apo AI synthesis (45%, P<0.05). We conclude that atorvastatin exerts additional beneficial effects on the metabolism of apo B containing lipoproteins unrelated to an increase in LDL receptor activity. Fenofibrate but not atorvastatin increases apo AI production and plasma turnover.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Atorvastatin	Approved	VLDL cholesterol	decreased	Atorvastatin decreases the level of VLDL cholesterol in the blood
Fenofibrate	Approved	Cholesterol	decreased	Fenofibrate decreases the level of Cholesterol in the blood
Atorvastatin	Approved	Cholesterol	decreased	Atorvastatin decreases the level of Cholesterol in the blood
Fenofibrate	Approved	HDL cholesterol	increased	Fenofibrate increases the level of HDL cholesterol in the blood
Atorvastatin	Approved	Triglycerides	decreased	Atorvastatin decreases the level of Triglycerides in the blood
Fenofibrate	Approved	VLDL cholesterol	decreased	Fenofibrate decreases the level of VLDL cholesterol in the blood
Atorvastatin	Approved	LDL cholesterol	decreased	Atorvastatin decreases the level of LDL cholesterol in the blood
Fenofibrate	Approved	Triglycerides	decreased	Fenofibrate decreases the level of Triglycerides in the blood
Atorvastatin	Approved	HDL cholesterol	increased	Atorvastatin increases the level of HDL cholesterol in the blood