Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes.

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Skrha J, Stulc T, Hilgertova J, Weiserova H, Kvasnicka J, Ceska R

Effect of simvastatin and fenofibrate on endothelium in Type 2 diabetes.

Eur J Pharmacol. 2004 Jun 16;493(1-3):183-9.

PubMed ID

15189781 [ View in PubMed

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Abstract

Statins and fibrates influence endothelial activity and consequently atherogenesis but the mechanisms are not well understood. Twenty Type 2 diabetic patients with dyslipidemia were treated 3 months with simvastatin (20 mg daily) and then 3 months with fenofibrate (200 mg daily) with 2 months of wash-out between the two treatments. Laboratory parameters of oxidative stress, fibrinolysis and endothelial function were evaluated before and at the end of each treatment period. The significant decrease in serum total and LDL-cholesterol concentrations (P<0.0001) caused by simvastatin was associated with an increase in serum N-acetyl-beta-glucosaminidase activity (P<0.001), ascorbic acid (P<0.001), plasminogen activator inhibitor (PAI-1) (P<0.01), vonWillebrand factor (P<0.05), E-selectin (P<0.01) and vascular endothelial growth factor (P<0.05) concentrations and with a decrease in plasma glutathione (P<0.01) levels. Fenofibrate caused a significant decrease in serum triglyceride concentration (P<0.0001) associated with a decrease in plasma malondialdehyde (P<0.001) and an increase in plasma PAI-1 (P<0.05) and P-selectin (P<0.05) concentrations. We conclude that simvastatin and fenofibrate interact, by different mechanisms, with oxidative stress, a key factor in the modification of fibrinolysis and endothelial function in Type 2 diabetes.

DrugBank Data that Cites this Article

Pharmaco-metabolomics

Drug	Drug Groups	Metabolite	Change	Description
Fenofibrate	Approved	Malondialdehyde	decreased	Fenofibrate decreases the level of Malondialdehyde in the blood
Simvastatin	Approved	Glutathione	decreased	Simvastatin decreases the level of Glutathione in the blood
Simvastatin	Approved	Ascorbic acid	increased	Simvastatin increases the level of Ascorbic acid in the blood
Simvastatin	Approved	Total cholesterol	decreased	Simvastatin decreases the level of Total cholesterol in the blood
Simvastatin	Approved	LDL cholesterol	decreased	Simvastatin decreases the level of LDL cholesterol in the blood