Limited value of cyclosporine A for the treatment of patients with uveitis associated with juvenile idiopathic arthritis.

Article Details

Citation
Copy to clipboard

Tappeiner C, Roesel M, Heinz C, Michels H, Ganser G, Heiligenhaus A

Limited value of cyclosporine A for the treatment of patients with uveitis associated with juvenile idiopathic arthritis.

Eye (Lond). 2009 May;23(5):1192-8. doi: 10.1038/eye.2008.174. Epub 2008 Jun 13.

PubMed ID
18551142 [ View in PubMed
]
Abstract

AIMS: Juvenile idiopathic arthritis (JIA) is often associated with severe chronic anterior uveitis (CAU), and immunosuppressive therapy may be required. In this study, the value of cyclosporine A (CsA) as monotherapy or as combination therapy for treating uveitis was studied in a large cohort of JIA children. METHODS: Multicentre retrospective study including 82 JIA children (girls n=60) suffering from unilateral or bilateral (n=55) CAU. The indication for CsA was active uveitis, although patients were on topical or systemic corticosteroids, MTX, or other immunosuppressive drugs. RESULTS: Inactivity of uveitis during the entire treatment period (mean 3.9 years) was obtained with CsA monotherapy in 6 of 25 (24%) patients, but more often when CsA was combined with the immunosuppressives (35/72 patients; 48.6%, P=0.037), or MTX (18/37 patients, 48.6%, P=0.065), which had already been given. With CsA (mean dosage 2.9 mg/kg), systemic immunosuppressive drugs and steroids could be reduced by >or=50% (n=19) or topical steroids reduced to

DrugBank Data that Cites this Article

Drugs