Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin.
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Premkumar VG, Yuvaraj S, Vijayasarathy K, Gangadaran SG, Sachdanandam P
Serum cytokine levels of interleukin-1beta, -6, -8, tumour necrosis factor-alpha and vascular endothelial growth factor in breast cancer patients treated with tamoxifen and supplemented with co-enzyme Q(10), riboflavin and niacin.
Basic Clin Pharmacol Toxicol. 2007 Jun;100(6):387-91.
- PubMed ID
- 17516992 [ View in PubMed]
- Abstract
The prognostic significance of supplementing co-enzyme Q(10) (CoQ(10)), riboflavin and niacin (CoRN) along with tamoxifen to breast cancer patients was evaluated by measuring the serum cytokine levels of interleukin (IL)-1beta, IL-6, IL-8, tumour necrosis factor alpha (TNF-alpha) and vascular endothelial growth factor. In the present study, 84 breast cancer patients were randomized to receive a daily supplement of CoQ(10) 100 mg, riboflavin 10 mg and niacin 50 mg, one dosage per day along with tamoxifen 10 mg twice a day. Serum cytokine levels were elevated in untreated breast cancer patients (Group II) and significantly reduced after tamoxifen therapy for more than 1 year (Group III). When group III breast cancer patients were supplemented with CoRN for 45 days (Group IV) and 90 days (Group V) along with tamoxifen, a significant reduction in cytokine levels were observed (P < 0.05). Such a decrease in serum cytokine levels after CoRN supplementation in breast cancer patients may suggest good prognosis and efficacy of the treatment, and might even offer protection from metastases and recurrence of cancer.
DrugBank Data that Cites this Article
- Pharmaco-proteomics
Drug Drug Groups Gene Gene ID Change Interaction Chromosome Tamoxifen Approved CXCL8 3576 decreased Tamoxifen results in decreased expression of CXCL8 protein 4q13.3 Tamoxifen Approved IL1B 3553 decreased Tamoxifen results in decreased expression of IL1B protein 2q14.1 Tamoxifen Approved IL6 3569 decreased Tamoxifen results in decreased expression of IL6 protein 7p15.3 Tamoxifen Approved TNF 7124 decreased Tamoxifen results in decreased expression of TNF protein 6p21.33