Adeno-associated virus vector integration.

Article Details

Citation

Copy to clipboard

Deyle DR, Russell DW

Adeno-associated virus vector integration.

Curr Opin Mol Ther. 2009 Aug;11(4):442-7.

PubMed ID

19649989 [ View in PubMed

]

Abstract

Adeno-associated virus (AAV) vectors efficiently transduce various cell types and can produce long-term expression of transgenes in vivo. Although AAV vector genomes can persist within cells as episomes, vector integration has been observed in various experimental settings, either at non-homologous sites where DNA damage may have occurred or by homologous recombination. In some cases, integration is essential for the therapeutic or experimental efficacy of AAV vectors. Recently, insertional mutagenesis resulting from the integration of AAV vectors was associated with tumorigenesis in mice, a consideration that may have relevance for certain clinical applications.

DrugBank Data that Cites this Article

Drugs

Voretigene neparvovec

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Voretigene neparvovec	Retinoid isomerohydrolase	Protein	Humans	Yes	Gene replacement	Details