The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer.

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Hyttel J, Bogeso KP, Perregaard J, Sanchez C

The pharmacological effect of citalopram residues in the (S)-(+)-enantiomer.

J Neural Transm Gen Sect. 1992;88(2):157-60.

PubMed ID

1632943 [ View in PubMed

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Abstract

The enantiomers of citalopram and N-demethylcitalopram have been investigated. Based on the inhibition of 5-HT uptake in vitro and the potentiation of 1-5-HTP in vivo the pharmacological activity resides in the (+)-enantiomers (the eutomers*) with the 1-(S) absolute configuration. In the 5-HT uptake test eudismic ratios of 167 and 6.6 are obtained for the enantiomers of citalopram and N-demethylcitalopram, respectively. The pharmacological profile of the eutomers of citalopram and N-demethylcitalopram very much resembles the profile of the respective racemates.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Torasemide	Solute carrier family 12 member 2	Protein	Humans	Yes	Inhibitor	Details