Human herpes simplex virus keratitis: the pathogenesis revisited.

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Remeijer L, Osterhaus A, Verjans G

Human herpes simplex virus keratitis: the pathogenesis revisited.

Ocul Immunol Inflamm. 2004 Dec;12(4):255-85. doi: 10.1080/092739490500363.

PubMed ID
15621867 [ View in PubMed
]
Abstract

Infections with several members of the human herpesviruses are the cause of significant ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent HSV-1 infection continues to be the leading cause of corneal blindness in industrialized nations. This review recapitulates the current insights in the role of the virus and the intra-corneal T cell response involved in the pathogenesis of human HSV-1-induced keratitis.

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