An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.

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Morales P, Reggio PH, Jagerovic N

An Overview on Medicinal Chemistry of Synthetic and Natural Derivatives of Cannabidiol.

Front Pharmacol. 2017 Jun 28;8:422. doi: 10.3389/fphar.2017.00422. eCollection 2017.

PubMed ID

28701957 [ View in PubMed

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Abstract

Cannabidiol (CBD) has been traditionally used in Cannabis-based preparation, however historically, it has received far less interest as a single drug than the other components of Cannabis. Currently, CBD generates considerable interest due to its beneficial neuroprotective, antiepileptic, anxiolytic, antipsychotic, and anti-inflammatory properties. Therefore, the CBD scaffold becomes of increasing interest for medicinal chemists. This review provides an overview of the chemical structure of natural and synthetic CBD derivatives including the molecular targets associated with these compounds. A clear identification of their biological targets has been shown to be still very challenging.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Cannabidiol	5-hydroxytryptamine receptor 2A	Protein	Humans	Unknown	Agonist	Details