Lack of interaction between tolcapone and tolbutamide in healthy volunteers.

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Jorga KM, Fotteler B, Gasser R, Banken L, Birnboeck H

Lack of interaction between tolcapone and tolbutamide in healthy volunteers.

J Clin Pharmacol. 2000 May;40(5):544-51.

PubMed ID

10806608 [ View in PubMed

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Abstract

To assess the effect of tolcapone (an inhibitor of cytochrome P450 [CYP] 2C9 in vitro) on the pharmacokinetics and hypoglycemic effect of the CYP 2C9 substrate tolbutamide, 12 healthy male volunteers were randomized to receive a single dose of tolbutamide 500 mg plus either placebo or tolcapone 200 mg after an overnight fast and 30 minutes after the start of a 6.5-hour 5% glucose infusion (150 mL/h). The participants crossed over to receive the alternative regimen after a washout period of at least 7 days. Tolcapone had no effect on the pharmacokinetics of tolbutamide or its metabolites and did not influence the effect of tolbutamide on plasma glucose concentrations. No serious adverse events or abnormal laboratory results or vital signs were reported. In conclusion, clinically relevant drug-drug interactions between tolcapone and tolbutamide when given together in clinical practice appear unlikely.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Tolcapone	Cytochrome P450 2C9	Protein	Humans	No	Inhibitor	Details