Muscarinic receptor subtypes in airways.

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Barnes PJ

Muscarinic receptor subtypes in airways.

Life Sci. 1993;52(5-6):521-7.

PubMed ID

8441331 [ View in PubMed

]

Abstract

Muscarinic receptor subtypes in the airways appear to subserve different physiological functions. M1-receptors facilitate neurotransmission through parasympathetic ganglia and enhance cholinergic reflexes, but are also localized to alveolar walls. M2-receptors act as autoreceptors on post-ganglionic cholinergic nerves and inhibit acetylcholine release. There is some evidence that they may be defective in asthma (as a consequence of airway inflammation?) and this may enhance cholinergic reflexes and account for beta-blocker-induced asthma. M2-receptors in airway smooth muscle may also counteract the bronchodilator action of beta-agonists. M3-receptors mediate contractile responses in airway smooth muscle via phosphoinositide hydrolysis, and are the predominant receptors on submucosal glands and airway vascular endothelium. M4- and M5-receptors have not been identified in human airways, but in rabbit lung M4-receptors are expressed on alveolar walls and smooth muscle. Anticholinergic drugs which selectively block M3 and M1-receptors may have an advantage over currently used non-selective antagonists in the treatment of airway obstruction.

DrugBank Data that Cites this Article

Drugs

Revefenacin

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Revefenacin	Muscarinic acetylcholine receptor (Protein Group)	Protein group	Humans	Yes	Antagonist	Details