Review: modifications of human serum albumin and their binding effect.

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Lee P, Wu X

Review: modifications of human serum albumin and their binding effect.

Curr Pharm Des. 2015;21(14):1862-5.

PubMed ID

25732553 [ View in PubMed

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Abstract

Human serum albumin (HSA) regulates the transport and availability of numerous chemical compounds and molecules in the blood vascular system. While previous HSA research has found that HSA interacts with specific varieties of ligands, new research efforts aim to expand HSA's ability to interact with more different drugs in order to improve the delivery of various pharmacological drugs. This review will cover fatty acid chain and posttranslational modifications of HSA that potentially modulate how HSA interacts with various pharmacological drugs, including glycation, cysteinylation, S-nitrosylation, S-transnitrosation and S-guanylation.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Albumin human	Nitric oxide	Small molecule	Humans	Unknown	Binder	Details