Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
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Shtivelman E, Lifshitz B, Gale RP, Roe BA, Canaani E
Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene.
Cell. 1986 Oct 24;47(2):277-84.
- PubMed ID
- 3021337 [ View in PubMed]
- Abstract
The primary structure of normal abl protein was determined by sequencing the coding region of its cDNA. abl contains two alternative 5' exons spliced to a common set of 3' exons to yield the two major abl RNA transcripts. These transcripts initiate in different promoter regions and give rise to proteins that vary in their N-termini. In the human cell line K562, abl is translocated from chromosome 9 to within the bcr gene on chromosome 22. Within the fused bcr-abl gene, abl exon II alternatively splices to two adjacent bcr exons. This phenomenon is seen in many patients with chronic myeloid leukemia.