Expression of active human factor VIII from recombinant DNA clones.

Article Details

Citation

Wood WI, Capon DJ, Simonsen CC, Eaton DL, Gitschier J, Keyt B, Seeburg PH, Smith DH, Hollingshead P, Wion KL, Delwart E, Tuddenham EG, Vehar GA, Lawn RM

Expression of active human factor VIII from recombinant DNA clones.

Nature. 1984 Nov 22-28;312(5992):330-7.

PubMed ID
6438526 [ View in PubMed
]
Abstract

DNA clones encoding the complete 2,351 amino acid sequence for human factor VIII have been isolated and used to produce biologically active factor VIII in cultured mammalian cells. The recombinant protein corrects the clotting time of plasma from haemophiliacs and has many of the biochemical and immunological characteristics of serum-derived factor VIII.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
Coagulation factor VIIIP00451Details