Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
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Green S, Walter P, Kumar V, Krust A, Bornert JM, Argos P, Chambon P
Human oestrogen receptor cDNA: sequence, expression and homology to v-erb-A.
Nature. 1986 Mar 13-19;320(6058):134-9.
- PubMed ID
- 3754034 [ View in PubMed]
- Abstract
We have cloned and sequenced the complete complementary DNA of the oestrogen receptor (ER) present in the breast cancer cell line MCF-7. The expression of the ER cDNA in HeLa cells produces a protein that has the same relative molecular mass and binds oestradiol with the same affinity as the MCF-7 ER. There is extensive homology between the ER and the erb-A protein of the oncogenic avian erythroblastosis virus.