Cloning and sequencing of human LH/hCG receptor cDNA.
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Minegishi T, Nakamura K, Takakura Y, Miyamoto K, Hasegawa Y, Ibuki Y, Igarashi M, Minegish T [corrected to Minegishi T]
Cloning and sequencing of human LH/hCG receptor cDNA.
Biochem Biophys Res Commun. 1990 Nov 15;172(3):1049-54.
- PubMed ID
- 2244890 [ View in PubMed]
- Abstract
We have isolated and sequenced a cDNA encoding the human luteinizing hormone--choriogonadotropin (LH/hCG) receptor. The deduced amino acid sequence (699 residues) containing seven putative transmembrane segments displays sequence similarity to G protein-coupled receptors. The receptor consists of 335 residue extracellular domain which contains six N-linked glycosylation sites. While the protein is 85 and 87% identical overall with the previously cloned rat and porcine LH/hCG receptor respectively, the most highly conserved regions are the putative transmembrane segments (91 and 94% similarity, respectively).