Activation of CCK-A receptors induces elevation of plasma corticosterone in rats.

Article Details

Citation

Copy to clipboard

Katsuura G, Ibii N, Matsushita A

Activation of CCK-A receptors induces elevation of plasma corticosterone in rats.

Peptides. 1992 Jan-Feb;13(1):203-5.

PubMed ID

1620654 [ View in PubMed

]

Abstract

Cholecystokinin octapeptide (CCK-8) and ceruletide (1 microgram/kg) produced a pronounced increment of plasma corticosterone levels at 30 min after intraperitoneal administration. The response to these peptides was suppressed by pretreatment with a selective antagonist for CCK-A receptors, (-)L-364,718, in a dose-related manner, but not with an antagonist for CCK-B receptors, (+)L-365,260. However, (-)L-364,718 itself had no effect on basal levels of plasma corticosterone. These results indicate that peripheral administration of CCK-8 and ceruletide stimulates the hypothalamo-pituitary adrenal axis through the activation of CCK-A receptors, but not CCK-B receptors.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ceruletide	Cholecystokinin receptor type A	Protein	Humans	Yes	Inducer	Details