Inhibitory effect of ceruletide on haloperidol-induced catalepsy in rats.

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Ibii N, Ikeda M, Takahara Y, Eigyo M, Akiyoshi T, Matsushita A

Inhibitory effect of ceruletide on haloperidol-induced catalepsy in rats.

Peptides. 1989 Jul-Aug;10(4):779-83.

PubMed ID

2587420 [ View in PubMed

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Abstract

Ceruletide (CLT: 160 micrograms/kg, SC) produced a relatively long-lasting inhibition of haloperidol (HPD: 2 mg/kg, PO) catalepsy in rats. Neither bilateral vagotomies nor hypophysectomy abolished the anticataleptic effect of CLT. However, (-)-L-364,718 and proglumide blocked the effect of CLT. CLT (160 micrograms/kg) significantly inhibited HPD (2 mg/kg)-induced increase in dopamine (DA) release from the rat striatum. This effect of CLT was also antagonized by proglumide. These results suggest that CLT (160 micrograms/kg) primarily acts on cholecystokinin-A receptor in the brain, exerts some modulatory influence on HPD binding to striatal DA receptors via unknown neural pathways and, consequently, inhibits HPD catalepsy.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Ceruletide	Cholecystokinin receptor type A	Protein	Humans	Yes	Inducer	Details