AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.

Article Details

Citation

Stapleton D, Woollatt E, Mitchelhill KI, Nicholl JK, Fernandez CS, Michell BJ, Witters LA, Power DA, Sutherland GR, Kemp BE

AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location.

FEBS Lett. 1997 Jun 16;409(3):452-6.

PubMed ID
9224708 [ View in PubMed
]
Abstract

The AMP-activated protein kinase (AMPK) consists of catalytic alpha and non-catalytic, beta and gamma (38 kDa) subunits and is responsible for acting as a metabolic sensor for AMP levels. There are multiple genes for each subunit and we find that rat liver AMPK-alpha2 isoform catalytic subunit is associated with beta1 and gamma1 and not with beta2 or gamma2 subunit isoforms. The beta1 and gamma1 isoforms are also subunits of the alpha1 isoform. The sequence of cloned human AMPK-beta1 is 95% identical in amino acid sequence with rat beta1. Human chromosomal localizations were determined for AMPK-alpha1 (5p11-p14), AMPK-beta1 (12q24.1-24.3) and AMPK-gamma1 (12q12-q14), respectively.

DrugBank Data that Cites this Article

Polypeptides
NameUniProt ID
5'-AMP-activated protein kinase subunit beta-1Q9Y478Details