AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Article Details
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Hardie DG
AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.
Nat Rev Mol Cell Biol. 2007 Oct;8(10):774-85.
- PubMed ID
- 17712357 [ View in PubMed]
- Abstract
The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates catabolic pathways and switches off protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.
DrugBank Data that Cites this Article
- Polypeptides
Name UniProt ID 5'-AMP-activated protein kinase subunit beta-1 Q9Y478 Details 5'-AMP-activated protein kinase catalytic subunit alpha-1 Q13131 Details 5'-AMP-activated protein kinase subunit beta-2 O43741 Details 5'-AMP-activated protein kinase catalytic subunit alpha-2 P54646 Details 5'-AMP-activated protein kinase subunit gamma-1 P54619 Details 5'-AMP-activated protein kinase subunit gamma-2 Q9UGJ0 Details 5'-AMP-activated protein kinase subunit gamma-3 Q9UGI9 Details